Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade.

We found a clear trend towards a positive correlation between the T-ratios of drug responsiveness and the fold increase of CD40 levels post D + T treatment (Spearman r = 0.6571, p = 0.0875).

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Here we are predominately studying the effect of RGS on ICD and downstream immune responses, so regardless of whether RGS is inducing ICD by directly inhibiting the RAS/RAF/MAPK/PI3K pathway or microtubules, the results are highly significant.

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