Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model.

Trends toward increased GlcCer in brain tissue from hom GBA1 D409V KI mice at 4 and 8 months of age relative to WT did not reach statistical significance ( p > 0.05; Fig 4A ).

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These results are largely consistent with another report of this model by Burbulla et al (2019) who found hippocampal levels of GlcCer unchanged and only a slight trend towards increased GlcSph in het mice at 13–15 months of age ( Table 1 ) [ 31 ].

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