Identification of DNA methylation biomarkers for risk of liver metastasis in early-stage colorectal cancer.

Clin Epigenetics · 2021 · PMC8190869 · PMID 34108011

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an overall trendno p-value reported

al has focused on genes expression regulated by DMRs in 106 CRC patients and found an overall trend toward hypermethylation in CRC tissue samples [ 16 ].

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a significant trendno p-value reported

Finally, we performed a Jonckheere trend test on the methylation levels of these DMRs, to identify any DMRs showing a significant trend in different cancer stages, including tumor-adjacent, stage I, II and IV.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.