Cytoplasmic RRM1 activation as an acute response to gemcitabine treatment is involved in drug resistance of pancreatic cancer cells.

PLoS One · 2021 · PMC8191885 · PMID 34111175

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did not reach statistical significanceno p-value reported

On the other hand, the difference between patients with pancreatic cancer with low and high RRM1 expression in the GEM group did not reach statistical significance, though there was a trend towards better survival treating with gemcitabine ( S4B Fig ).

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highly significantno p-value reported

Please discuss the negative PFS with adjuvant therapy but the highly significant OS.

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