A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor.

Of the five genome-wide significant loci in the meta-analysis, rs28971325, rs1042704 and rs2472660 associated with Dupuytren’s disease at the genome-wide significant level, rs17570529 was nominally significant (p = 1x10 -5 ), and rs2472660 did not associate (p = 0.21) ( Table 3 ).

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This is very marginally significant (if you were to Bonferroni correct your seven univariable tests), and is not significant in the multivariable model.

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