High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation.

An IFNγ ELISA was used to measure the quantity of IFNγ in serum and revealed an increase in the levels of IFNγ measured following vaccination in five of the six BCG vaccinated animals relative to the unvaccinated group although the difference did not reach statistical significance (p = 0.179).

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