Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice.

The score of C3 deposits in mice studied 40 days after cell injection was still lower than PBS-treated mice, but the difference did not reach statistical significance (Fig. 2 B, C). hAEC treatment was associated with a remarkable and significant reduction in glomerular deposits of C9 in mice 10 days after cell injection, compared to control mice (Fig. 2 D, E), though this effect was lost 40 days after cell injection (Fig. 2 D, E). hAEC ameliorated the glomerular ultrastructure of Cfh −/− mice Cfh −/− mice developed subendothelial electron-dense deposits at ultrastructural analysis at 2 months of age, culminating in urinary protein loss at 8 months of age [ 19 ].

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