Identification and characterization of lncRNA AP000253 in occult hepatitis B virus infection.

However, unexpectedly, the level of AP00253 was higher in HBV-expressing hepatoma cell lines, despite the difference did not reach statistical significance in Huh7/pHBV1.3 cell line (Fig. 5 B). lncRNA AP000253 promoted HBV replication in human hepatoma cell lines Finally, to gain further insight into the biological roles of AP000253 in HBV infection, AP000253 over-expression plasmid (pcDNA3.1/ AP000253 ) and knockdown plasmid (si- AP000253 ) were generated and transfected into Huh7/pHBV1.3 and HepG2.2.15 cells.

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