The lower mortality did not reach statistical significance for IFN-β (OR = 0.28, 95% CI (0.03,2.33)) (P = 0.24) ( Shalhoub et al., 2015 ). 3.8 Inflammatory cytokines 3.8.1 COVID-19 A cohort study showed that during the time interval of day 0–20 (upon onset of symptoms), on average, cases receiving the ARB only regimen had higher CRP levels than cases treated with IFN alone or both IFN and ARB, by 25.7 mg/l.
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Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies.
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