Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients.

As displayed by Figure 3 A, neurons from both P149 lines and P34 2 show as compared to CTLRs neurons a visible reduction of nuclear area, quantified by scoring 50 neurons per sample, as highly significant ( p value < 0.0001) ( Figure 3 C).

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TSA significantly reduced this parameter for P149 lines ( p value < 0.0001), while P34 neurons showed a trend to correction of this ratio, as quantified by the graphs in Figure 4 D.

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