Identification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico-Vaginal Fluid Using LC-MS/MS.

In total, 18 (CRNN, DDX3X/DDX3Y/DDX4, DESP, DHB4, DSG3, ELAF, GBP6, K1C14, K1C16, K2C1, LEG7, PKP1, PKP3, PLAK, SPR1A, SPR1B, SPR2A, and TGM1, Figure 2 ) of these 207 proteins were found to have nominally significant ( p < 0.05, Wilcoxon ranked sum test) differences in abundance levels between cases and controls.

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Furthermore, five of the samples were characterized with MS in duplicates (separate punches from the same FTA card), providing highly significant correlations between replicates ( p < below machine precision, 2.2 × 10 −16 ).

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