Impact of SGLT2 Inhibitors on Heart Failure: From Pathophysiology to Clinical Effects.

Besides, the more widespread use of other hypoglycemic drugs with proven cardiorenal benefits would have rendered it more difficult to reach a significance, even in the presence of a favorable trend, although it cannot be excluded that small differences between drugs in the class result in different outcomes.

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This positive finding was mainly ascribed to the reduction in HF hospitalizations (HR 0.69, 95% CI 0.59–0.81), whereas the reduction in CV death did not reach statistical significance (HR 0.92, CI 95% 0.75–1.12).

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