A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.

A similar trend was observed in the subiculum region but did not reach statistical significance ( Fig 1B ).

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Grn +/− mice have also been shown to have marginally significant reduction in plaque numbers and plaque area in female mice at 16–18 mo, although limited number of mice were used in the study ( Hosokawa et al, 2018 ).

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