32 In the REHAB‐HF pilot study, a 12‐week rehabilitation programme focused on improving strength, balance, mobility, and endurance showed a trend towards improved physical function and decreased hospitalizations in acute HF patients. 33 Recent evidence suggests that exercise training, combined with nutritional support (e.g. protein/amino acid supplementation, preventing vitamin/mineral deficiencies), has shown considerable benefit in chronic HF patients. 6 , 34 Assessment of urinary creatinine at baseline and during such studies would be of great interest to illustrate an improvement of muscle mass during exercise intervention studies.
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The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure.
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