Fibromyalgia and Nociceptive Flexion Reflex (NFR) Threshold: A Systematic Review, Meta-Analysis, and Identification of a Possible Source of Heterogeneity.

25 Results from the contour-funnel precision plot is as the following: i) effect sizes are non-significant ( P > 0.1): Four trials were present in this zone that indicates that their effect sizes were not different from zero; ii) effect sizes are marginally non-significant (0.05 < P < 0.1): none of the studies fell inside this area; iii) effect sizes are different from zero (0.01 < P < 0.05): none of the trials’ effect sizes are located inside this category; iv) effect sizes are highly statistically different than zero ( P < 0.01): Five trials (55%) had highly significant effect sizes from which 4 trials (80%) indicated deficits in NFRthr in FM patients compared to healthy controls and 1 trial (20%) found positive difference in NFRthr means in FM patients and healthy individuals.

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On a side note, while running meta-regressions we speculated whether the ratios of male or female to total sample size could be a significant determinant of the effect size of which none was meaningfully significant.

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