A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.

In 23andMe research cohort, 45 out of 51 lead SNPs available (88.2%) replicated with a consistent direction of effect at a Bonferroni corrected significance threshold of 9.8 × 10 −4 ( P -value = 0.05/51) and additional 2 SNPs were nominally significant ( P < 0.05) (Table 1 and Supplementary Fig. 4 ).

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