Y disruption, autosomal hypomethylation and poor male lung cancer survival.

Sci Rep · 2021 · PMC8203787 · PMID 34127738

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantP = 3.72 × 10 –28actually significant

Sex-related tissue specificity One network specific to histologically normal tissue (Normal: lavenderblush3) featured a highly significant relationship with biological sex (bicor 0.82 P = 3.72 × 10 –28 , n Obs = 113, see Supplementary Fig.

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nominally significantP ≤ 0.05actually significant

Survival analysis incorporating low KDM5D as a prognostic indicator yielded nominally significant P -values ( P ≤ 0.05) in seven cancers types, most significantly in head-neck squamous cell carcinoma (n 366, HR 1.79 [95% CI 1.3, 2.5], P = 0.0003) and liver hepatocellular carcinoma (n 249, HR 1.85 [95% CI 1.16, 2.94], P = 0.008).

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