In this regard, it is noteworthy that sham-operated mice that expressed ChR2 in Mrgprd Cre lineage afferents also showed a trend toward avoidance of the blue side of the RTPA chamber that was greater than that observed in naive mice, although not as pronounced as that observed in SNI mice.
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MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.
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