Temperature dependent viral tropism: understanding viral seasonality and pathogenicity as applied to the avoidance and treatment of endemic viral respiratory illnesses.

28 Another study using a type‐15 rhinovirus did find that 16% more of the chilled group developed colds than the unchilled one, but, because the results did not reach statistical significance, the authors reported a ‘failure to demonstrate effect’. 91 Moreover, the strain used was isolated eight years before the study and grown in WI‐26 cells, a cell‐line that is routinely propagated at 37°C. 92 It is therefore likely that this strain, like many other laboratory strains, had lost much of its natural thermal sensitivity by the time the study was carried out.

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