Compared with the 130 d-old ALS model, cluster 1 and 2 of spinal cord showed a trend toward an increase of proteins involved in muscle contraction, cardiac muscle contraction, immune response regulation of muscle contraction, skeletal muscle contraction (Figure 2 D), innate immune response, immune system process and inflammatory response, among others (Figure 2 E).
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R13 preserves motor performance in SOD1<sup>G93A</sup> mice by improving mitochondrial function.
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