Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions.

Were the behavioral data in figure 2B from both controls and wLH mice separate that underwent photometry recordings? Were any recordings performed in control animals? The Reviewers noted a small difference across days 1 and 2 in baseline performance of animals prior to LH induction; however, this difference did not reach statistical significance on a two-way ANOVA post hoc comparison: We included new behavioral data in the control group for obtaining photometry recordings discussed in the paragraph below (Figure 2—figure supplement 3) and carried out two-way ANOVA analysis in panel 2b to compare escape behaviors across different days and between groups (control vs wLH).

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