Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines.

CFA increased by 12% in the PERT group and declined by 8% in the control group, but this difference did not reach statistical significance (p=0.13). 77 An RCT in Korea failed to observe any benefit of PERT on body weight (p=0.381), subjective global assessment (p=0.18) or survival (p=0.744) compared with placebo over an 8-week period in 67 patients with unresectable PC. 76 It should be noted that patients were not permitted to receive H2-receptor antagonists or proton-pump inhibitors (PPIs) and, consequently, PERT may not have been effective without adequate neutralisation of gastric acid.

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