Interplay of Forces and the Immune Response for Functional Tendon Regeneration.

To investigate that, a study showed that highly aligned fibers mitigate adverse tendon fibroblast response to paracrine signals or secreted pro-inflammatory cytokines of macrophages, by means of changing the matrix topography ( Schoenenberger et al., 2018 ), and in this case, macrophages also showed a trend to M2-like polarization ( Schoenenberger et al., 2020 ).

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