Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.

The average severity of alveolitis and bronchitis was also numerically lower in the selinexor-treated animals, but the difference did not reach statistical significance ( Fig. 6 B and C). 3.4 Selinexor inhibits inflammatory cytokine expression by LPS-stimulated human PBMCs As described above, selinexor as well as other SINE compounds force the nuclear retention and functional activation of IκB and other anti-inflammatory proteins, leading to attenuation of NF-κB and other pro-inflammatory transcription factors ( Widman et al., 2018 ; Wu et al., 2018 ).

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