The adaptive benefit of evolved increases in hemoglobin-O₂ affinity is contingent on tissue O₂ diffusing capacity in high-altitude deer mice.

Instead, the observed variation in V̇ O 2 max appeared to be associated with variation in heart rate, which was also significantly affected by inspired P O 2 (P < 0.0001), though the effect of genotype was only marginally significant (P = 0.0545; Additional file 5 : Fig.

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