Tofacitinib for the Treatment of Ulcerative Colitis: Analysis of Infection Rates from the Ulcerative Colitis Clinical Programme.

Older age is associated with an increased risk of herpes zoster both in the general population 2 , 36 and in patients with IBD, 5 and the risk factors identified here are consistent with findings from the RA and psoriasis programmes, where similar risk factors were identified, with the exception of baseline corticosteroid use and Asian race, which did not reach statistical significance in our modelling. 13 , 37 However, a previous study in tofacitinib-treated patients with UC identified Asian race to be associated with increased risk for herpes zoster. 15 North American geographical region as a risk factor for herpes zoster has not previously been reported; however, it is possible that geographical differences in vaccination recommendations and uptake may contribute to herpes zoster risk.

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