Adjuvant brachytherapy for FIGO stage I serous or clear cell endometrial cancer.

To minimize statistical error, given the overall low event rate, only associates that were significant or near significance in univariate modeling were analyzed in a multivariate model.

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We conclude that vaginal cuff brachytherapy is a reasonable option in appropriately selected women with surgically staged, high-risk, early-stage endometrial cancer; however, this analysis demonstrates a clear trend in pathological factors that portend to worse disease control and long-term survival, which should be considered for escalation of care.

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