Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.

PRG4 expression was also positively corelated with plaque burden volume ratio (wall volume divided by vessel volume inclusive of lumen and wall, r = 0.452, p = 0.003) and showed a negative trend with lipid rich necrotic core volume (LRNC Vol Prop: LRNC volume as a proportion of total wall volume, r = −0.268, p = 0.095), but these associations were not independent ( Figure 1 C and Table S1 ). 3.2.

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Concomitantly with the resolution phase of the injury response (2–12 weeks), Prg4 levels returned to a baseline and showed a positive trend in association with the recovery of typical SMC markers.

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