The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells.

Indeed, patient data support this notion since PDAC patients harboring TP53 R248Q or TP53 R248W mutations showed a trend for reduced survival compared to patients with loss-of-function NS+FS mutation ( Figure 5E ), supporting the mutp53 R248W -pSTAT3 complex as a potentially attractive target in PDAC.

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