The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner.

IL-6 levels were significantly increased at 5 dpi with overall time-dependent elevation in IL-6 transcripts ( Figure 3 E); TNFα levels, while not statistically significant, showed a trend of upregulation over time ( Figure 3 D).

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While there is variability in CXCL9 and CXCL10 gene expression among animals, there is an evident trend towards upregulation of transcripts over time with large increases in transcript level elevation at days 2–5 with increasing statistical significance when compared to uninfected (0 dpi).

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