Proteomic Profiling of BRAFV600E Mutant Colon Cancer Cells Reveals the Involvement of Nucleophosmin/c-Myc Axis in Modulating the Response and Resistance to BRAF Inhibition by Vemurafenib.

Int J Mol Sci · 2021 · PMC8228139 · PMID 34201061

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showed a trendno p-value reported

Amongst all studied proteins, only the expression levels of NPM1 and phospho-c-Myc (Ser62) showed a trend towards an increase in both BRAF-mutated cell lines ( Figure 3 ), albeit statistically non-significant when compared to other cell lines.

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