No hepatotoxicity or kidney injury associated with the injection of tL-5G3 was found in the serum liver transaminase and creatinine analysis ( Figure 1 f), while at a dose of 10 mg/kg, tinyLNA showed a trend of liver and kidney injury ( Figure 1 b), whose toxic potential was also partially observed in previous studies [ 15 ].
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Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides.
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