Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.

These studies indicated that 24 h following incubation with the glycolysis inhibitor, p65 activation by TNFα + IL-1β was reduced in both TNBC cells ( Figure 9 B); here again, downregulation of p65 by the glycolysis inhibitor (2-DG) in MDA-MB-231 cells was consistent in three different independent experiments ( p = 0.0505; Table S7B ); however, they came out only close-to-significant when considered all together ( Figure 9 B2) because of variability that was noted between the different experiments in the levels of phosphorylation in cells without inhibitors, and in the extent of decrease in p65 induced by 2-DG ( Table S7B ).

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