Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice.

In the same fashion, there was a slightly significant difference ( p = 0.011) between the 1 μL and 10 μL DTaP groups in the locomotion assay ( Figure 4 b); however, the heroin-induced hyperlocomotion was still reduced in these two groups compared to the control animals.

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