Separating the Wheat from the Chaff: The Use of Upstream Regulator Analysis to Identify True Differential Expression of Single Genes within Transcriptomic Datasets.

Three genes ( Bcl2l1 , Ilk , Mfsd2a ) showed statistically significant upregulation in DEX-treated mice ( Figure 3 B–D), while Pdk4 and Kyat3 showed a trend toward upregulation in DEX-treated mice ( Figure 3 E; Supplementary File, Figure S2B ).

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