Restrictive versus liberal fluid resuscitation strategy, influence on blood loss and hemostatic parameters in mild obstetric hemorrhage: An open-label randomized controlled trial. (REFILL study).

Even though we reached our aimed pre-calculated sample size, and the point estimate of the difference in risk of progression to more than 1000 mL blood loss pointed to a clinically relevant effect (absolute difference, 12.1%; number needed to treat, 9), the difference did not reach statistical significance (p = 0.057).

also in 111,027 other papers