<i>CD101</i> genetic variants modify regulatory and conventional T cell phenotypes and functions.

2 We also identified four missense variants that alter amino acids in the cytoplasmic domain of the protein ( Figure S1 ) and are associated with an increase in HIV-1 acquisition risk that did not reach statistical significance after adjustment for multiple comparisons. 2 Previous studies have shown that the CD101 gene encodes a transmembrane protein highly expressed on T cells, monocytes, and dendritic cells. 3 Early studies have demonstrated that T cell receptor (TCR) cross-linking induces expression of CD101 on human T cells 4 , 5 and that proliferation of T cells in response to stimulation with anti-CD3 is inhibited by treatment with an anti-CD101 antibody, 3 , 6 , 7 suggesting that CD101 plays a role in TCR-dependent T cell activation.

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