Interestingly, Slco2b1 (-/-) mice showed a trend towards a decrease in the k 2 parameter ( Figure 7 ), which may be related to a reduced expression of hepatic MRP3 which was shown to mediate the efflux of [ 99m Tc]mebrofenin from the liver into the blood [ 21 ].
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Imaging-Based Characterization of a <i>Slco2b1<sup>(-/-)</sup></i> Mouse Model Using [<sup>11</sup>C]Erlotinib and [<sup>99m</sup>Tc]Mebrofenin as Probe Substrates.
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