Relevance of Human Papillomaviruses in Head and Neck Cancer-What Remains in 2021 from a Clinician's Point of View?

For HPV-driven cancers, the follow-up time within national HPV vaccination programs is still too short to evaluate the effect [ 86 ], although a positive trend has recently been demonstrated in one of the major HPV vaccine trials [ 92 ].

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Probably due to the significantly higher HPV prevalence rates described for TSCC and OPSCC with a supposedly higher clinical relevance, a clear trend has developed worldwide to examine almost exclusively oropharyngeal SCC instead of analyzing all tumor sites from the head and neck region for HPV infections.

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