Furthermore, the mRNA levels of IL-10 and Ym1 detected in the hippocampus of Tβ4 intervention mice were significantly increased than that of APP/PS1 mice, suggesting a restoration of microglia inner homeostasis, and Fizz1 mRNA level also showed a trend of elevation (Fig. 5 h–j).
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Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
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