Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized <sup>13</sup> C-MRI.

19 , 33 , 34 At 24 h we observed no changes in the Lac/Pyr ratio for all tumor types following 6‐Gy radiation, a finding similar to that of Day et al., who treated C6 bearing rats with a single dose of 15 Gy and showed a trend, but nonsignificant drop in Lac/Pyr at 24 h that became significant at 72‐h postradiation. 35 This comparison highlights another important experimental consideration, which is the dose and frequency of the radiation used.

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