Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.

Lastly, we investigated the effect of the TBC1D4 –physical activity interaction on other cardiometabolic traits and found nominally significant effects on waist/hip ratio (β[interaction] = −0.00026 / [kJ kg −1 day −1 ], p = 0.047, n = 2872; ESM Table 2 ) and insulin sensitivity index (β[interaction] = 0.0024 / [kJ kg −1 day −1 ], p = 0.045, n = 2634; ESM Table 2 ).

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