Defining the resilience of the human salivary microbiota by a 520-day longitudinal study in a confined environment: the Mars500 mission.

Stable ASVs—namely those grouped into Cluster 2 according to their prevalence in time—that showed a significant trend of diversity enriched the saliva of four out of six crewmembers, if compared with the overall occurrence (Fig. 5 b).

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The fecal microbiota of the same crewmembers showed an increasing trend of similarity among subjects, especially in relation to a sharing of rare taxa [ 17 ], indicating that salivary microbiota has a more pronounced personalization than fecal microbiota.

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