The time to peak blood bicarbonate (HCO3-), pH, and the strong ion difference (SID) following sodium bicarbonate (NaHCO3) ingestion in highly trained adolescent swimmers.

Did the authors perform an a-priori power analysis? I am afraid that a lot of statistical effects failed to reach significance as the power of the study was too low? • L178: Why did the authors perform a paired t-test and not an unpaired t-test when comparing participants that co-ingested other supplements and those who did not? • L198 – figure 1.

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• L135-137: Did the authors perform some correlation analyses to assess whether the macronutrient composition of the pre-exercise meal is related to the pharmacokinetics of the increase in SID? • L171: A lot of results were almost significant (p values between 0.05 and 0.10) and effect sizes were quite large.

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The SID increased by 2.0 ± 1.5 mEq∙L -1 (+6%, p = 0.024) at 60 min post-ingestion and peaked at 135 min post-ingestion (+2.4 ± 2.6 mEq∙L -1 , +7%), however, this did not reach statistical significance.

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