A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism.

A similar pattern was observed for SMS, SMOX and SRM, all of which were associated with poor prognosis in LIHC, while the others did not show any highly significant difference (SMS; HR 1.9, p = 7e−04; SMOX: HR 1.7, p = 0.003; SRM: HR 1.7, p = 0.03).

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Our results show an overall pattern of increased expression of the HBP enzymes in many tumors; however, none of the genes were upregulated as strongly as the enzymes of glycolysis and most of the upregulations did not reach statistical significance (Supplementary Fig.

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