DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study.

Clin Epigenetics · 2021 · PMC8252231 · PMID 34210361

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

marginal significanceP = 0.08so close (0.05 < p ≤ 0.1)

The associations with the CBCL internalizing subscale were not significant, and only marginal significance was achieved for CpG-1 ( P = 0.08), CpG-2 ( P = 0.06), and CpG-7 ( P = 0.08) on the CBCL total scale.

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nominally significantno p-value reported

Further, methylation levels of multiple CpGs in MAOA showed nominally significant association with externalizing behavior on the CBCL, and the methylation level of one CpG in AR showed nominally significant association with the BRIEF Regulation Index.

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