Mean baseline levels of IL-6, IL-8, IL-10 and TNF were all numerically lower in patients with a PFS longer than 6 months (after TIL infusion) compared with patients with PFS shorter than 6 months (after TIL infusion; online supplemental figure S3A–D ); however, the difference did not reach statistical significance when cytokines were evaluated individually (IL-6: P 0.25; IL-8: P 0.17; IL-10: P 0.09; TNF: P 0.24).
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Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma.
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