Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population.

SNP rs2241164 was also nominally significant in the independent replication sample ( P = 0.0462, OR = 1.110), and the significance became stronger in a subsequent meta-analysis combining both discovery and replication samples ( P = 0.00398, OR = 1.138).

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Notably, inconsistencies between genetic studies in smaller samples and in large GWAS are often observed, i.e., SNPs of certain genes (such GAD1) may be significant in smaller samples, but not significant in large GWAS cohorts.

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