Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.

In SZ patients (Table 3 ), a marginally significant negative correlation between MPF in WM and age was found.

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SZ patients with negative symptoms also showed a trend of an MPF reduction relative to the patients with positive symptoms in all tissues, while the significant difference was observed for WM only (Table 2 ).

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