Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors.

Results Genetic correlations Using genome-wide LD score regression analyses, we found non-significant negative genetic correlation ( r g ) between neuroticism and BMI ( r g = −0.0174 (SE 0.0213), P = 0.413) and HDL ( r g = −0.0216 (SE 0.0244), P = 0.3765) and positive genetic correlation with neuroticism that was nominally significant for CAD ( r g = 0.0919 (SE 0.0289), P = 0.0015), TG ( r g = 0.0367 (SE 0.0182), P = 0.0432), WHR ( r g = 0.065 (SE 0.0269), P = 0.0159), and non-significant for DBP ( r g = 0.0333 (SE 0.0272), P = 0.2209), SBP ( r g = 0.0426 (SE 0.025), P = 0.0893), CRP ( r g = 0.0313 (SE 0.0273), P = 0.2526), CIGPRDAY ( r g = 0.0445 (SE 0.0572), P = 0.4371), T2D ( r g = 0.0377 (SE 0.0337), P = 0.2638), LDL ( r g = 0.0308 (SE 0.026), P = 0.2351), and TC ( r g = 0.0333 (SE 0.0256), P = 0.1936) (Suppl.

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